pI: 9.5918 |
Length (AA): 634 |
MW (Da): 69965 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 270 | 2ivx (A) | 8 | 261 | 24.00 | 0 | 1 | 0.96 | -1.42 |
6 | 285 | 1h1r (B) | 185 | 431 | 19.00 | 0 | 1 | 0.82 | -0.71 |
10 | 288 | 2b9r (A) | 16 | 257 | 16.00 | 0 | 1 | 0.474763 | 0.4 |
13 | 253 | 3blh (B) | 19 | 245 | 29.00 | 0 | 1 | 0.686826 | -0.62 |
252 | 603 | 4kf7 (A) | 1 | 354 | 9.00 | 0 | 0.02 | 0.613905 | -0.24 |
274 | 327 | 3ol2 (B) | 293 | 352 | 39.00 | 0.22 | 0.09 | 0.386974 | 0.78 |
338 | 607 | 4wj1 (A) | 17 | 286 | 14.00 | 0 | 0.01 | 0.569568 | -0.66 |
423 | 535 | 1vq8 (P) | 18 | 117 | 27.00 | 0.37 | 0.09 | 0.332033 | -0.94 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | VEG Tachyzoite, ME49 Tachyzoite, ME49 merozoite, ME49 Oocyst, ME49 Bradyzoite. | Gregory Hehl AB Fritz HM Sibley/Greg |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Ortholog group members (OG5_128974)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G26430 | ania-6a type arginine-rich cyclin |
Babesia bovis | BBOV_IV006560 | cyclin 4 |
Brugia malayi | Bm1_55065 | LOC443688 protein |
Caenorhabditis elegans | CELE_C52E4.6 | Protein CYL-1, isoform A |
Dictyostelium discoideum | DDB_G0285553 | hypothetical protein |
Drosophila melanogaster | Dmel_CG16903 | CG16903 gene product from transcript CG16903-RA |
Echinococcus granulosus | EgrG_000439400 | Cyclin L1 |
Echinococcus multilocularis | EmuJ_000439400 | Cyclin L1 |
Homo sapiens | ENSG00000221978 | cyclin L2 |
Homo sapiens | ENSG00000163660 | cyclin L1 |
Loa Loa (eye worm) | LOAG_06815 | hypothetical protein |
Mus musculus | ENSMUSG00000027829 | cyclin L1 |
Mus musculus | ENSMUSG00000029068 | cyclin L2 |
Neospora caninum | NCLIV_040480 | hypothetical protein |
Oryza sativa | 4325450 | Os01g0377500 |
Onchocerca volvulus | OVOC6931 | Cyclin L homolog |
Plasmodium berghei | PBANKA_1403200 | cyclin, putative |
Plasmodium falciparum | PF3D7_1304700 | cyclin |
Plasmodium knowlesi | PKNH_1404900 | cyclin 4, putative |
Plasmodium vivax | PVX_122075 | cyclin 4, putative |
Plasmodium yoelii | PY00225 | Cyclin, putative |
Schistosoma japonicum | Sjp_0005500 | Cyclin-L2, putative |
Schistosoma mansoni | Smp_039670 | cyclin l |
Schmidtea mediterranea | mk4.000958.08 | Cyclin L |
Toxoplasma gondii | TGME49_264690 | cyclin 4, putative |
Theileria parva | TP01_1216 | cyclin, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C52E4.6 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_C52E4.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C52E4.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C52E4.6 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_C52E4.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_C52E4.6 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1403200 | Plasmodium berghei | Essential | plasmo |
TGME49_264690 this record | Toxoplasma gondii | Essentiality uncertain | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.3